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ELA2, Rabbit, Clone: SP203, Abnova™

Catalog No. 89110312 Shop All Abnova Corporation Products
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89-110-312 100 μL
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Catalog No. 89-110-312 Supplier Abnova Corporation Supplier No. MAB12171

Description

Rabbit monoclonal antibody raised against synthetic peptide of human ELA2.

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

Specifications

Antigen ELA2
Applications Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SP203
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of human ELA2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
Gene ELA2
Gene Alias GE/HLE/HNE/NE/PMN-E
Gene Symbols ELA2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human ELA2.
Purification Method Protein A/G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1991
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG
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