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ELA2 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89121425 Shop All Abnova Corporation Products
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150 μg
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Catalog No. Quantity
89-121-425 150 μg
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Catalog No. 89-121-425 Supplier Abnova Corporation Supplier No. PAB19913
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Description

Rabbit polyclonal antibody raised against native ELA2.

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

Specifications

Antigen ELA2
Applications ELISA
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against native ELA2.
Dilution The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.5 (0.02% sodium azide, 50% glycerol (v/v))
Gene ELA2
Gene Alias GE/HLE/HNE/NE/PMN-E
Gene Symbols ELA2
Host Species Rabbit
Immunogen Native purified ELA2 from human neutrophil.
Purification Method Affinity purification
Quantity 150 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1991
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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