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ERBB2, Rabbit, Clone: A24-V, Abnova™

Catalog No. 89113765 Shop All Abnova Corporation Products
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89-113-765 100 μL
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Catalog No. 89-113-765 Supplier Abnova Corporation Supplier No. MAB9764
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Description

Rabbit monoclonal antibody raised against synthetic peptide of ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Specifications

Antigen ERBB2
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone A24-V
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of ERBB2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:300) The optimal working dilution should be determined by the end user.
Formulation In 20mM Tris-HCl, pH 8.0 (20mg/mL BSA, 0.05% sodium azide)
Gene ERBB2
Gene Accession No. P04626
Gene Alias CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Gene Symbols ERBB2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus of human ERBB2.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2064
Target Species Human, Mouse
Content And Storage Store at 4°C.
Form Liquid
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For Research Use Only

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