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ERBB2 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89117262 Shop All Abnova Corporation Products
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89-117-262 100 μL
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Catalog No. 89-117-262 Supplier Abnova Corporation Supplier No. PAB14782

Description

Rabbit polyclonal antibody raised against synthetic peptide of ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Specifications

Antigen ERBB2
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of ERBB2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene ERBB2
Gene Alias CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Gene Symbols ERBB2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues surrounding Y1248 of human ERBB2.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2064
Test Specificity Molecular weight: 185 KDa. Epitope: Around tyrosine 1248.
Target Species Human
Content And Storage Store at 4°C. Do not freeze.
Form Liquid
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