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ERBB3 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ERBB3.

Manufacturer:  Abnova Corporation PAB14785

Catalog No. 89-117-264

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq

Specifications

Specifications

ERBB3
Lot specific
Rabbit polyclonal antibody raised against synthetic peptide of ERBB3.
In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Liquid
ERBB3
A synthetic peptide corresponding to internal region of human ERBB3.
100 uL
Store at 4°C. Do not freeze.
Polyclonal
Molecular weight: 185 KDa. Epitope: Internal region.
Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
ERBB3
ErbB-3|HER3|LCCS2|MDA-BF-1|MGC88033|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Rabbit
Immunoaffinity purification
RUO
Primary
2065
Human
SDS
Documents
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