ERBB4 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ERBB4.

Supplier:  Abnova Corporation PAB16287

Catalog No. 89-118-161

Description

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq

Specifications

• Antigen: ERBB4
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of ERBB4.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: Q15303
• Gene Symbols: ERBB4
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human ERBB4.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: Internal domain of human.
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15-30 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: ERBB4
• Gene Alias: HER4/MGC138404/p180erbB4
• Host Species: Rabbit
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 2066
• Target Species: Human
• Form: Liquid

For Research Use Only