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MilliporeSigma™ Rabbit anti-ERLIN1/SPFH1, Polyclonal,

Catalog No. ABS1611MI Shop All MilliporeSigma Products
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ABS1611MI 200 μL
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Rabbit Polyclonal Antibody

Specifically detects ERLIN1/SPFH1 in Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting

ER lipid raft associated 1 (UniProt B1WBY7; also known as Protein Erlin1, SPFH domain family, member 1) is encoded by the Erlin1 (also known as RGD1307058 or Spfh1_predicted) gene in rat (Entrez Gene ID 293939; ORF rCG_57742). Erlin1 (Spfh1) and the highly homologous Erlin2 (Spfh2) are ER proteins that hetero-oligomerize into a large complex of ∽2MDa. The erlin1/2 complex associates with inositol 1,4,5-trisphosphate (IP(3)) receptors on ER membrane and is responsible for recruiting RNF170 upon IP(3) receptor activation for subsequent ubiquitination-dependent receptor downregulation (PMID 19240031, 21610068, 22020079). ERLIN1/SPFH1, C-terminus, is an affinity purified rabbit polyclonal antibody against rat Erlin1/Spfh1 C-terminal end sequence. This polyclonal antibody is reactive toward rat and murine, but not human, species (PMID 19240031).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERLIN1/SPFH1
Applications Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Formulation Purified rabbit polyclonal in buffer containing 155mM NaCl, 50mM Tris-HCl pH 7.4, with 0.05% sodium azide and 10% glycerol.
Gene Accession No. B1WBY7
Gene Symbols Erlin1; Spfh1_predicted; rCG_57742
Host Species Rabbit
Immunogen Linear peptide corresponding to the C-terminus of rat ERLIN1/SPFH1.
Purification Method Affinity Purified
Quantity 200 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_001099823
Target Species Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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