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F13A1, Rabbit, Clone: SP196, Abnova™

Catalog No. 89109391 Shop All Abnova Corporation Products
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89-109-391 100 μL
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Catalog No. 89-109-391 Supplier Abnova Corporation Supplier No. MAB11220

Description

Rabbit monoclonal antibody raised against synthetic peptide of F13A1.

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq

Specifications

Antigen F13A1
Applications Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SP196
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of F13A1.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
Gene F13A1
Gene Alias F13A
Gene Symbols F13A1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to N-terminus region of human F13A1.
Purification Method Protein A/G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2162
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG
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