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F8, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89128714 Shop All Abnova Corporation Products
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Catalog No. Quantity
89-128-714 100 μL
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Catalog No. 89-128-714 Supplier Abnova Corporation Supplier No. PAB27064
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Description

Rabbit polyclonal antibody raised against synthetic peptide of F8.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]

Specifications

Antigen F8
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of F8.
Dilution Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.2 (0.05% sodium azide)
Gene F8
Gene Accession No. P00451
Gene Alias AHF/DXS1253E/F8B/F8C/FVIII/HEMA
Gene Symbols F8
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human F8.
Purification Method Antigen affinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2157
Test Specificity F8 polyclonal antibody detects endogenous levels of F8 protein.
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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