FANCD2 (phospho S222), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of FANCD2.

Supplier:  Abnova Corporation PAB12530

Catalog No. 89-115-905

Description

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq

Specifications

• Antigen: FANCD2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of FANCD2.
• Formulation: No additive
• Gene Alias: DKFZp762A223/FA-D2/FA4/FACD/FAD/FAD2/FANCD/FLJ23826
• Host Species: Rabbit
• Quantity: 200 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody is specific to the phosphorylated form of FANCD2.
• Content And Storage: Store at -20°C or -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Western Blot
• Conjugate: Unconjugated
• Dilution: The optimal working dilution should be determined by the end user.
• Gene: FANCD2
• Gene Symbols: FANCD2
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding S222 of human FANCD2.
• Regulatory Status: RUO
• Gene ID (Entrez): 2177
• Target Species: Human
• Form: Liquid

For Research Use Only