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FANCD2 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No. 89115801 Shop All Abnova Corporation Products
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89-115-801 50 μL
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Catalog No. 89-115-801 Supplier Abnova Corporation Supplier No. PAB12428
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Description

Rabbit polyclonal antibody raised against partial recombinant FANCD2.

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq

Specifications

Antigen FANCD2
Applications Immunofluorescence, Immunohistochemistry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against partial recombinant FANCD2.
Dilution Immunofluorescence (1:200-1:500) Western Blot (1:10000-1:20000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5-5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In Tris-glycine, 150mM NaCl (0.05% sodium azide)
Gene FANCD2
Gene Accession No. Q9BXW9
Gene Alias DKFZp762A223/FA-D2/FA4/FACD/FAD/FAD2/FANCD/FLJ23826
Gene Symbols FANCD2
Host Species Rabbit
Immunogen Recombinant protein corresponding to N-terminus of human FANCD2.
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2177
Test Specificity This antibody is specific to FANCD2.
Target Species Human, Mouse
Content And Storage Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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