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FBXW7, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89134470 Shop All Abnova Corporation Products
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100 μg
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Catalog No. Quantity
89-134-470 100 μg
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Catalog No. 89-134-470 Supplier Abnova Corporation Supplier No. PAB9873
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Description

Rabbit polyclonal antibody raised against synthetic peptide of FBXW7.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]

Specifications

Antigen FBXW7
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of FBXW7.
Dilution Western Blot (1-5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.08% sodium azide)
Gene FBXW7
Gene Alias AGO/CDC4/DKFZp686F23254/FBW6/FBW7/FBX30/FBXO30/FBXW6/FLJ16457/SEL-10/SEL10
Gene Symbols FBXW7
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human FBXW7.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55294
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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