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FCGR3A, Rabbit, Clone: SP175, Abnova™

Catalog No. 89110297 Shop All Abnova Corporation Products
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89-110-297 100 μL
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Catalog No. 89-110-297 Supplier Abnova Corporation Supplier No. MAB12156

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Rabbit monoclonal antibody raised against synthetic peptide of human FCGR3A.

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen FCGR3A
Applications Flow Cytometry, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SP175
Conjugate Unconjugated
Description Rabbit monoclonal antibody raised against synthetic peptide of human FCGR3A.
Dilution Flow Cytometry (1:100) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.6 (1% BSA, 0.09% sodium azide)
Gene FCGR3A
Gene Alias CD16/CD16A/FCG3/FCGR3/FCGRIII/FCR-10/FCRIII/FCRIIIA/IGFR3
Gene Symbols FCGR3A
Host Species Rabbit
Immunogen A synthetic peptide corresponding to C-terminus region of human FCGR3A.
Purification Method Protein A/G purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2214
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
Isotype IgG
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For Research Use Only

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