FGFR1 (phospho Y766), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of FGFR1.

Supplier:  Abnova Corporation PAB0472

Catalog No. 89-114-241

Description

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq

Specifications

• Antigen: FGFR1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of FGFR1.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: NP_075598;P11362
• Gene Symbols: FGFR1
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y766 of human FGFR1.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-100) Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Gene: FGFR1
• Gene Alias: BFGFR/CD331/CEK/FGFBR/FLG/FLJ99988/FLT2/HBGFR/KAL2/N-SAM
• Host Species: Rabbit
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 2260
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only