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FGFR3 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89115256 Shop All Abnova Corporation Products
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89-115-256 100 μL
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Catalog No. 89-115-256 Supplier Abnova Corporation Supplier No. PAB11649

Description

Rabbit polyclonal antibody raised against synthetic peptide of FGFR3.

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq

Specifications

Antigen FGFR3
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Concentration Lot specific
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of FGFR3.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:25) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide)
Gene FGFR3
Gene Alias ACH/CD333/CEK2/HSFGFR3EX/JTK4
Gene Symbols FGFR3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids 359-372 of human FGFR3.
Purification Method Immunoaffinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2261
Target Species Human
Content And Storage Store at 4°C.
Form Liquid
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