FGFR4, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-130-800	400 μL

Catalog No. 89-130-800 Supplier Abnova Corporation Supplier No. PAB3044

Description

Rabbit polyclonal antibody raised against synthetic peptide of FGFR4.

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq

Specifications

• Antigen: FGFR4
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of FGFR4.
• Dilution: Western Blot (1:1000) Immunohistochemistry (1:50-100) Flow cytometry (1:10-50) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: FGFR4
• Gene Accession No.: P22455
• Gene Alias: CD334/JTK2/MGC20292/TKF
• Gene Symbols: FGFR4
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human FGFR4.
• Purification Method: Protein G purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2264
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only