FLT3 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of FLT3.

Supplier:  Abnova Corporation PAB16428

Catalog No. 89-118-301

Description

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq

Specifications

• Antigen: FLT3
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of FLT3.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: P36888
• Gene Symbols: FLT3
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human FLT3.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: Internal domain of human.
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: FLT3
• Gene Alias: CD135/FLK2/STK1
• Host Species: Rabbit
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 2322
• Target Species: Human
• Form: Liquid

For Research Use Only