FLT3 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-118-301	50 μg

Catalog No. 89-118-301 Supplier Abnova Corporation Supplier No. PAB16428

Description

Rabbit polyclonal antibody raised against synthetic peptide of FLT3.

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq

Specifications

• Antigen: FLT3
• Applications: Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of FLT3.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (8 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: FLT3
• Gene Accession No.: P36888
• Gene Alias: CD135/FLK2/STK1
• Gene Symbols: FLT3
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human FLT3.
• Purification Method: Immunoaffinity purification
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2322
• Test Specificity: Internal domain of human.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only