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FZD6, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89127850 Shop All Abnova Corporation Products
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89-127-850 50 μg
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Catalog No. 89-127-850 Supplier Abnova Corporation Supplier No. PAB26210
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Description

Rabbit polyclonal antibody raised against synthetic peptide of FZD6.

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Specifications

Antigen FZD6
Applications Immunocytochemistry, Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of FZD6.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (6-14 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene FZD6
Gene Accession No. O60353
Gene Alias Hfz6
Gene Symbols FZD6
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acid at N-terminus of human FZD6.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8323
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD3 (50%).
Target Species Human, Monkey
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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