MilliporeSigma™ Rabbit anti-GPR98, Polyclonal,

Catalog No.	Quantity
ABN1377	100 μg

Catalog No. ABN1377 Supplier MilliporeSigma™ Supplier No. ABN1377

Description

Rabbit Polyclonal Antibody

Specifically detects GPR98 in Human samples, and it is validated for Immunohistochemistry

G-protein coupled receptor 98 (UniProt Q8WXG9; also known as Monogenic audiogenic seizure susceptibility protein 1 homolog, Usher syndrome type-2C protein, Very large G-protein coupled receptor 1) is encoded by the GPR98 (also known as KIAA0686, KIAA1943, MASS1, USH2C, VLGR1) gene (Gene ID 84059) in human. GPR98, also known as Very Large GPCR receptor 1 (Vlg1R1), is the largest G-protein-coupled receptor (GPCR) known. It is an adhesion-GPCR family receptor expressed in the central nervous system. GPR98 is produced with a signal peptide (a.a. 1-29) sequence, the removal of which yields the mature seven-transmembrane (a.a. 5909-5929, 5940-5960, 5980-6000, 6011-6031, 6060-6080, 6105-6125, 6134-6154) protein with a C-termiinal cytoplasmic domain (a.a. 6155-6306) and a large N-terminal extracellular region (a.a. 30-5908) that contains six epilepsy-associated repeats or EAR domains (a.a. 3189-3534) sandwiched between two clusters of calcium-binding Calx-beta repeats (Calx-beta 1-22/a.a. 30-3172 and Calx-beta 23-35/a.a. 3525-5468), as well as a GPCR-proteolytic site (GPS; a.a. 5853-5902) proximal to the first transmembrane helix. The extreme carboxy-terminus contains a consensus PDZ ligand sequence, suggesting interactions with other cytosolic or cytoskeletal proteins. Although the GPR98 ligand is yet to be identified, GPR98 gene mutations are linked to one form (2C) of Usher syndrome, the most common genetic cause of combined blindness and deafness.

Specifications

• Antigen: GPR98
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Accession No.: Q8WXG9
• Gene Symbols: GPR98; KIAA0686; KIAA1943; MASS1; USH2C; VLGR1
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to a sequence from the second Calx-beta repeat of human GPR98.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Neuroscience
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_115495
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only