GRM1 Rabbit anti-Human, Monkey, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-128-052	50 μg

Catalog No. 89-128-052 Supplier Abnova Corporation Supplier No. PAB26410

Description

Rabbit polyclonal antibody raised against synthetic peptide of GRM1.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq

Specifications

• Antigen: GRM1
• Applications: Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of GRM1.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: GRM1
• Gene Accession No.: Q13255
• Gene Alias: GPRC1A/GRM1A/MGLUR1/MGLUR1A/mGlu1
• Gene Symbols: GRM1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to 16 amino acids at C-terminus of human GRM1.
• Purification Method: Immunoaffinity chromatography
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2911
• Test Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Target Species: Human, Monkey
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only