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GRM2 Rabbit anti-Dog, Hamster, Human, Rabbit, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89128154 Shop All Abnova Corporation Products
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50 μg
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89-128-154 50 μg
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Catalog No. 89-128-154 Supplier Abnova Corporation Supplier No. PAB26514
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Description

Rabbit polyclonal antibody raised against synthetic peptide of GRM2.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen GRM2
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of GRM2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (32 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene GRM2
Gene Accession No. Q14416
Gene Alias GLUR2/GPRC1B/MGLUR2/mGlu2
Gene Symbols GRM2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 18 amino acids at N-terminal extracellular domain of human GRM2.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2912
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM3 (50%).
Target Species Canine, Hamster, Human, Rabbit, Rat
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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