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GRM5 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Catalog No. 89121570 Shop All Abnova Corporation Products
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400 μL
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89-121-570 400 μL
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Catalog No. 89-121-570 Supplier Abnova Corporation Supplier No. PAB2007
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Description

Rabbit polyclonal antibody raised against synthetic peptide of GRM5.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Specifications

Antigen GRM5
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of GRM5.
Dilution Western Blot (1:1000) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene GRM5
Gene Accession No. NP_000833;P41594-2
Gene Alias GPRC1E/MGLUR5/mGlu5
Gene Symbols GRM5
Host Species Rabbit
Immunogen A synthetic peptide (conjugated with KLH) corresponding to C-terminus residues surrounding T1003 of human GRM5.
Purification Method Protein G purification
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2915
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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