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GRM6 Rabbit anti-Bovine, Dog, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89128141 Shop All Abnova Corporation Products
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50 μg
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89-128-141 50 μg
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Catalog No. 89-128-141 Supplier Abnova Corporation Supplier No. PAB26500
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Description

Rabbit polyclonal antibody raised against synthetic peptide of GRM6.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq

Specifications

Antigen GRM6
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of GRM6.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (12 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene GRM6
Gene Accession No. O15303
Gene Alias CSNB1B/DKFZp686H1993/GPRC1F/MGLUR6/mGlu6
Gene Symbols GRM6
Host Species Rabbit
Immunogen A synthetic peptide corresponding to N-terminus of human GRM6.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2916
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (73%), GRM4 (67%).
Target Species Bovine, Canine, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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