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HAAO Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89118604 Shop All Abnova Corporation Products
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100 μg
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89-118-604 100 μg
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Catalog No. 89-118-604 Supplier Abnova Corporation Supplier No. PAB16785
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Description

Rabbit polyclonal antibody raised against synthetic peptide of HAAO.

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq

Specifications

Antigen HAAO
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of HAAO.
Dilution Western Blot (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.02% sodium azide)
Gene HAAO
Gene Alias 3-HAO/HAO
Gene Symbols HAAO
Host Species Rabbit
Immunogen A synthetic peptide corresponding to N-terminus 17 amino acids of human HAAO.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23498
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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