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Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Specifications
Specifications
| Antigen | HDAC5 |
| Applications | ChIP Assay, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of HDAC5. |
| Dilution | The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.05% sodium azide) |
| Gene | HDAC5 |
| Gene Alias | FLJ90614/HD5/NY-CO-9 |
| Gene Symbols | HDAC5 |
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