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MilliporeSigma™ Rabbit anti-ICAT, Polyclonal,

Catalog No. ABC939MI Shop All MilliporeSigma Products
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ABC939MI 100 μg
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Catalog No. ABC939MI Supplier MilliporeSigma™ Supplier No. ABC939
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Description

Rabbit Polyclonal Antibody

Specifically detects ICAT in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting

Beta-catenin-interacting protein 1 (UniProt Q9NSA3; also known as Beta-catenin-interacting protein ICAT, Inhibitor of beta-catenin and Tcf-4) is encoded by the CTNNBIP1 (also known as ICAT) gene (Gene ID 56998) in human. Inhibitor of beta-catenin and TCF (ICAT) negatively regulates T-cell factor/lymphoid enhancer factor (TCF/LEF)–beta-catenin transcriptional activity by competing against TCF/LEF for beta-catenin binding. ICAT gene knockout leads to premature death of newborn mice with gut, kidney, and craniofacial anomalies, implicating an important role of ICAT in epithelial establishment/maintenance and neural crest cell differentiation. The motility of melanoma cells through 3D matrices in vitro relies on two interconvertible modes of movements. ICAT is reported to suppress the expression of developmentally downregulated 9 (NEDD9) of Wnt/beta-catenin signaling pathway in human Lu1205 melanoma cells, resulting in a shift from the Rac-dependent mesenchymal movement to the Rho/ROCK-dependent amoeboid motility in vitro and enhanced colonization of transplanted Lu1205 in the lungs of nude mice in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ICAT
Applications Immunocytochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Formulation Purified rabbit polyclonal antibody in buffer containing PBS with 0.05% sodium azide.
Gene Accession No. Q9NSA3
Gene Symbols CTNNBIP1; ICAT
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to the C-terminus of human ICAT.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Apoptosis, Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_064633
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
Form Purified
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For Research Use Only

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