MilliporeSigma™ Rabbit anti-IDH1, Polyclonal,

Catalog No.	Quantity
ABC1483MI	100 μg

Catalog No. ABC1483MI Supplier MilliporeSigma™ Supplier No. ABC1483

Description

Rabbit Polyclonal Antibody

Specifically detects IDH1 in Human samples, and it is validated for Western Blotting

Isocitrate dehydrogenase 1 (IDH1) is a 46kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into α-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.

Specifications

• Antigen: IDH1
• Applications: Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
• Gene Accession No.: O75874
• Gene Symbols: IDH1; PICD
• Host Species: Rabbit
• Immunogen: IDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Apoptosis, Cancer
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only