MilliporeSigma™ Rabbit anti-IKK beta, Polyclonal,

Catalog No.	Quantity
ABS810MI	100 μg

Catalog No. ABS810MI Supplier MilliporeSigma™ Supplier No. ABS810

Description

Rabbit Polyclonal Antibody

Specifically detects IKK beta in Human samples, and it is validated for Immunocytochemistry, Western Blotting

IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquitination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Specifications

• Antigen: IKK beta
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
• Gene Accession No.: O14920
• Gene Symbols: IKBKB; IKKB
• Host Species: Rabbit
• Immunogen: IKK beta antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Signaling
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only