MilliporeSigma™ Rabbit anti-IL-21, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABF184

Catalog No. ABF184MI

Description

Specifically detects IL-21 in Human samples, and it is validated for Flow Cytometry, Western Blotting

Interleukin-21 (UniProt Q9HBE4; also known as IL-21, Za11) is encoded by the IL21 (also known as CVID11) gene (Gene ID 59067) in human. IL-21 is a type I four-alpha-helical bundle cytokine primarily produced by CD4+ T cells and NKT cells. The heterodimeric receptor IL-21R is dominantly expressed by B cells and shares the common cytokine receptor gamma chain (γc) with receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. Studies indicate that IL-21 potently regulates both adaptive and innate immune responses and possesses widely pleiotropic functions. IL-21 has also been linked to autoimmune disorders, allergies, inflammatory diseases, as well as the pathogenesis of cancer. Human IL-21 is initially translated with an N-terminal 22 aa signal peptide sequence, which is later removed to produce the 133 aa mature IL-21.

Specifications

• Antigen: IL-21
• Classification: Polyclonal
• Gene Accession No.: Q9HBE4
• Host Species: Rabbit
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human

• Applications: Flow Cytometry, Western Blot
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: IL21
• Immunogen: KLH-conjugated linear peptide corresponding to human IL-21 sequence near the C-terminus.
• Quantity: 100 μg
• Research Discipline: Inflammation and Immunology
• Gene ID (Entrez): NP_068575
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only