ITCH, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ITCH.

Supplier:  Abnova Corporation PAB29228

Catalog No. 89-130-663

Description

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq

Specifications

• Antigen: ITCH
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ITCH.
• Formulation: In PBS, pH 7.4 (without Mg²⁺ and Ca²⁺), (50% glycerol, 0.02% sodium azide)
• Gene Alias: AIF4/AIP4/NAPP1/dJ468O1.1
• Host Species: Rabbit
• Purification Method: Affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 83737
• Target Species: Human, Mouse
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
• Gene: ITCH
• Gene Symbols: ITCH
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y420 of human ITCH.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: This antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.
• Content And Storage: Store at -20°C.
  Avoid repeated freezing and thawing.

For Research Use Only