JAK1, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-127-008	100 μg

Catalog No. 89-127-008 Supplier Abnova Corporation Supplier No. PAB25367

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of JAK1.

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq

Sequence: K-E-Yp-Y-T

Specifications

• Antigen: JAK1
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of JAK1.
• Dilution: Western Blot (1:500-1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (without Mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene: JAK1
• Gene Alias: JAK1A/JAK1B/JTK3
• Gene Symbols: JAK1
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Y1022 of human JAK1.
• Purification Method: Affinity purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3716
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only