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LATS1, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89121652 Shop All Abnova Corporation Products
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400 μL
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Catalog No. Quantity
89-121-652 400 μL
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Catalog No. 89-121-652 Supplier Abnova Corporation Supplier No. PAB2015
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Description

Rabbit polyclonal antibody raised against synthetic peptide of LATS1.

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq

Specifications

Antigen LATS1
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of LATS1.
Dilution Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene LATS1
Gene Alias WARTS/wts
Gene Symbols LATS1
Host Species Rabbit
Immunogen A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LATS1.
Purification Method Protein G purification
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9113
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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