MAP2K3 (phospho T222), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-130-644	100 μL

Catalog No. 89-130-644 Supplier Abnova Corporation Supplier No. PAB29210

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP2K3.

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq

Specifications

• Antigen: MAP2K3
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP2K3.
• Dilution: Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.4 (without Mg²⁺ and Ca²⁺), (50% glycerol, 0.02% sodium azide)
• Gene: MAP2K3
• Gene Alias: MAPKK3/MEK3/MKK3/PRKMK3
• Gene Symbols: MAP2K3
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T222 of human MAP2K3.
• Purification Method: Affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5606
• Test Specificity: This antibody detects endogenous levels of MAP2K3 only when phosphorylated at threonine 222.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at -20°C.
  Avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only