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MAP2K3 (phospho T222), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP2K3.

Supplier:  Abnova Corporation PAB29210

Catalog No. 89-130-644


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Description

Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq

Specifications

Specifications

MAP2K3
Polyclonal
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MAP2K3.
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
MAPKK3/MEK3/MKK3/PRKMK3
Rabbit
Affinity purification
RUO
5606
Human, Mouse, Rat
Liquid
Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user.
MAP2K3
MAP2K3
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T222 of human MAP2K3.
100 μL
Primary
This antibody detects endogenous levels of MAP2K3 only when phosphorylated at threonine 222.
Store at -20°C.
Avoid repeated freezing and thawing.
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