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MAP3K3, Rabbit, Polyclonal Antibody, Abnova™

Catalog No. 89128519 Shop All Abnova Corporation Products
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89-128-519 100 μL
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Catalog No. 89-128-519 Supplier Abnova Corporation Supplier No. PAB26874
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Description

Rabbit polyclonal antibody raised against synthetic peptide of MAP3K3.

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq

Specifications

Antigen MAP3K3
Applications Immunofluorescence, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of MAP3K3.
Dilution Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.2 (0.05% sodium azide)
Gene MAP3K3
Gene Alias MAPKKK3/MEKK3
Gene Symbols MAP3K3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to human MAP3K3.
Purification Method Affinity purification
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4215
Test Specificity MAP3K3 polyclonal antibody detects endogenous levels of MAP3K3 protein.
Target Species Human, Mouse
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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