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MAP3K8 Rabbit anti-Bovine, Human, Monkey, Polyclonal Antibody, Abnova™

Catalog No. 89127673 Shop All Abnova Corporation Products
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89-127-673 50 μg
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Catalog No. 89-127-673 Supplier Abnova Corporation Supplier No. PAB26034
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Description

Rabbit polyclonal antibody raised against synthetic peptide of MAP3K8.

This gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq

Specifications

Antigen MAP3K8
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of MAP3K8.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene MAP3K8
Gene Alias COT/EST/ESTF/FLJ10486/TPL2/Tpl-2/c-COT
Gene Symbols MAP3K8
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 19 amino acids at N-terminus of human MAP3K8.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1326
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Target Species Bovine, Human, Monkey
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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