MAPK8 (phospho T183/Y185), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-115-966	100 μg

Catalog No. 89-115-966 Supplier Abnova Corporation Supplier No. PAB12630

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAPK8.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Sequence: TPY

Specifications

• Antigen: MAPK8
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAPK8.
• Dilution: Western Blot (0.1-1 ug/mL) ELISA (0.01-0.1 ug/mL) Immunoprecipitation (2-5 ug/mL) Immunohistochemistry (1:50) The optimal working dilution should be determined by the end user.
• Formulation: In TBS, pH 7.2 (BSA, 10% Proclin300)
• Gene: MAPK8
• Gene Alias: JNK/JNK1/JNK1A2/JNK21B1/2/PRKM8/SAPK1
• Gene Symbols: MAPK8
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide corresponding to residues surrounding T183/Y185 of human MAPK8.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5599
• Test Specificity: This antibody recognizes human MAPK8.
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C. For long term storage store at -20 to -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG

For Research Use Only