MBD1 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-113-999	100 μg

Catalog No. 89-113-999 Supplier Abnova Corporation Supplier No. PAB0172

Description

Rabbit polyclonal antibody raised against synthetic peptide of MBD1.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq

Sequence: RQVGPQSGEVRKEAPR, SESEDGAGSPPPYRR

Specifications

• Antigen: MBD1
• Applications: Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MBD1.
• Dilution: The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.02% sodium azide)
• Gene: MBD1
• Gene Alias: CXXC3/PCM1/RFT
• Gene Symbols: MBD1
• Host Species: Rabbit
• Immunogen: A mixture of synthetic peptides corresponding to amino acids 98-113 and 391-405 of human MBD1.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4152
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only