MBD2 Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MBD2.

Supplier:  Abnova Corporation PAB2234

Catalog No. 89-124-047

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq

Specifications

• Antigen: MBD2
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MBD2.
• Formulation: In PBS (0.09% sodium azide)
• Gene Alias: DKFZp586O0821/DMTase/NY-CO-41
• Host Species: Rabbit
• Purification Method: Protein G purification
• Regulatory Status: RUO
• Gene ID (Entrez): 8932
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Dilution: Western Blot (1:1000) The optimal working dilution should be determined by the end user.
• Gene: MBD2
• Gene Symbols: MBD2
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MBD2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Form: Liquid

For Research Use Only