MBD4 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-116-900	100 μL

Catalog No. 89-116-900 Supplier Abnova Corporation Supplier No. PAB14057

Description

Rabbit polyclonal antibody raised against synthetic peptide of MBD4.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq

Specifications

• Antigen: MBD4
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MBD4.
• Dilution: ELISA (1:100-1:1000) Western Blot (1:2 000) The optimal working dilution should be determined by the end user.
• Formulation: In serum (0.05% sodium azide)
• Gene: MBD4
• Gene Alias: MED1
• Gene Symbols: MBD4
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human MBD4.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8930
• Target Species: Human
• Content And Storage: Store at -20°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only