MC1R, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MC1R.

Supplier:  Abnova Corporation PAB25002

Catalog No. 89-126-679

Description

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and nonmelanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq

Specifications

• Antigen: MC1R
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Western Blot (1:500-1:1000) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
• Gene: MC1R
• Gene Symbols: MC1R
• Immunogen: A synthetic peptide corresponding to MC1R.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: MC1R polyclonal antibody detects endogenous levels of MC1R.
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

• Applications: Immunofluorescence, Western Blot
• Concentration: 1 mg/mL
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MC1R.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene Alias: MGC14337/MSH-R/SHEP2
• Host Species: Rabbit
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 4157
• Target Species: Human
• Form: Liquid

For Research Use Only