MC1R, Rabbit, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-126-679	100 μL

Catalog No. 89-126-679 Supplier Abnova Corporation Supplier No. PAB25002

Description

Rabbit polyclonal antibody raised against synthetic peptide of MC1R.

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and nonmelanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq

Specifications

• Antigen: MC1R
• Applications: Immunofluorescence, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MC1R.
• Dilution: Western Blot (1:500-1:1000) Immunofluorescence (1:50-1:200) The optimal working dilution should be determined by the end user.
• Formulation: In PBS, pH 7.2 (0.05% sodium azide)
• Gene: MC1R
• Gene Alias: MGC14337/MSH-R/SHEP2
• Gene Symbols: MC1R
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to MC1R.
• Purification Method: Antigen affinity purification
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4157
• Test Specificity: MC1R polyclonal antibody detects endogenous levels of MC1R.
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only