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MDC1 (phospho S513), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.

Supplier:  Abnova Corporation PAB29247

Catalog No. 89-130-683


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Description

Description

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq

Specifications

Specifications

MDC1
Polyclonal
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
DKFZp781A0122/KIAA0170/MGC166888/NFBD1
Rabbit
Affinity purification
RUO
9656
Human
Liquid
Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
MDC1
MDC1
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S513 of human MDC1.
100 μL
Primary
This antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.
Store at -20°C.
Avoid repeated freezing and thawing.
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