MDC1 (phospho S513), Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
Supplier: Abnova Corporation PAB29247
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
|In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
|Immunohistochemistry (PFA fixed)
|Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
|Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S513 of human MDC1.
|This antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.
|Store at -20°C.
Avoid repeated freezing and thawing.
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