MDM2 (phospho T218), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-118-292	400 μL

Catalog No. 89-118-292 Supplier Abnova Corporation Supplier No. PAB1642

Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of MDM2.

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq

Specifications

• Antigen: MDM2
• Applications: Dot Blot, ELISA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of MDM2.
• Dilution: Dot Blot (1:500) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: MDM2
• Gene Alias: HDMX/MGC71221/hdm2
• Gene Symbols: MDM2
• Host Species: Rabbit
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T218 of human MDM2.
• Purification Method: Protein A purification
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4193
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only