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MDM2 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MDM2.

Manufacturer:  Abnova Corporation PAB18426

Catalog No. 89-119-988


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Description

Description

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq

Specifications

Specifications

MDM2
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of MDM2.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Liquid
MDM2
A synthetic peptide corresponding to human MDM2.
100 ug
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Polyclonal
This antibody is specific to MDM2.
ELISA, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (1:50-1:100) Immunofluorescence (1:500-1:1000) ELISA (1:20000) The optimal working dilution should be determined by the end user.
MDM2
HDMX|MGC71221|hdm2
Rabbit
Affinity purification
RUO
Primary
4193
Human
SDS
Documents
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