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MDM2 (phospho S186/S188), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89130721 Shop All Abnova Corporation Products
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Quantity:
100 μL
Catalog No. Quantity
89-130-721 100 μL
1 options

Catalog No. 89-130-721

Supplier: Abnova Corporation PAB29284

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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDM2.

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq

Specifications

Antigen MDM2
Applications Immunofluorescence
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDM2.
Dilution Immunofluorescence (1:100∼1:200) The optimal working dilution should be determined by the end user.
Formulation In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene MDM2
Gene Alias HDMX/MGC71221/hdm2
Gene Symbols MDM2
Host Species Rabbit
Immunogen Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S186/S188 of human MDM2.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4193
Test Specificity MDM2 (phospho S186/S188) polyclonal antibody detects endogenous levels of human MDM2 only when phosphorylated at serine 186 and serine 188.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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