MDM2 (phospho S186/S188), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDM2.
Supplier: Abnova Corporation PAB29284
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDM2.|
|In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Human, Mouse, Rat|
|Immunofluorescence (1:100∼1:200) The optimal working dilution should be determined by the end user.|
|Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S186/S188 of human MDM2.|
|MDM2 (phospho S186/S188) polyclonal antibody detects endogenous levels of human MDM2 only when phosphorylated at serine 186 and serine 188.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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