MilliporeSigma™ Rabbit anti-MICA, Polyclonal,

Catalog No.	Quantity
ABF317MI	100 μg

Catalog No. ABF317MI Supplier MilliporeSigma™ Supplier No. ABF317

Description

Rabbit Polyclonal Antibody

Specifically detects MICA in Human samples, and it is validated for Immunohistochemistry, Western Blotting

The protein MHC class 1 polypeptide-related sequence A (MIC-A) and encoded by the human gene named MICA is an unusual MHC class one molecule with no known role in antigen presentation but instead acts as a stress-induced self antigen that is recognized by gamma delta T cells and is the ligand for KLRK1/NKG2D cellular receptor. Binding to KLRK1 leads to cell lysis. MICA is a cell membrane associated protein found in the cytoplasm. Additionally, it is expressed in many organ systems and found expressed on many cell types. Expression is induced by many stress responses, including infection, DNA damaging agents, E. coli contact, hCMV and ionizing radiation. MICA is also the antigen for many autoimmune diseases associated with the skin, one organ system where MICA is highly expressed. Psoriasis and Psoriatic arthritis are two such diseases and antibodies to MICA have also been associated with organ transplant difficulties and allograft rejection.

Specifications

• Antigen: MICA
• Applications: Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Formulation: Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
• Gene Accession No.: Q29983
• Gene Symbols: MICA; PERB11.1
• Host Species: Rabbit
• Immunogen: MICA antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MICA.
• Purification Method: Affinity Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Inflammation and Immunology
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only