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Description
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. [provided by RefSeq]
Specifications
Specifications
| Antigen | MLH1 |
| Applications | Immunohistochemistry (PFA fixed) |
| Classification | Polyclonal |
| Concentration | Lot specific |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of MLH1. |
| Dilution | Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:100) The optimal working dilution should be determined by the end user. |
| Formulation | In 10mM PBS, pH 7.4 (1% BSA, 0.09% sodium azide) |
| Gene | MLH1 |
| Gene Alias | COCA2/FCC2/HNPCC/HNPCC2/MGC5172/hMLH1 |
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