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MilliporeSigma™ Rabbit anti-monomethyl Histone H3 (Lys4), Clone: RM140,

Catalog No. MABE636MI Shop All MilliporeSigma Products
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MABE636MI 100 μg
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Catalog No. MABE636MI Supplier MilliporeSigma™ Supplier No. MABE636
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Description

Rabbit Monoclonal Antibody

Specifically detects monomethyl Histone H3 (Lys4) clone: RM140 in Human samples, and it is validated for Western Blotting

Histone H3, also known as Histone H3.1t (H3/t), H3t, H3/g, and encoded by the gene name HIST3H3/ H3FT, is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Therefore, histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. High levels of phosphorylation of Histone H3 are associated with mitosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen monomethyl Histone H3 (Lys4)
Applications Western Blot
Classification Monoclonal
Clone RM140
Formulation Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.
Gene Accession No. P84243
Gene Symbols H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B
Host Species Rabbit
Immunogen A linear peptide corresponding to human Histone H3 monomethylated at Lys4.
Purification Method Protein A Purfied
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Form Purified
Isotype IgG
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For Research Use Only

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