Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. MABE643MI

MilliporeSigma™ Rabbit anti-monomethyl Histone H3 (Lys79), Clone: RM147,

Catalog No. MABE643MI Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
MABE643MI 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. MABE643MI Supplier MilliporeSigma™ Supplier No. MABE643
Add to Cart
Add to Cart

Description

Rabbit Monoclonal Antibody

Specifically detects monomethyl Histone H3 (Lys79) clone: RM147 in Human samples, and it is validated for Western Blotting

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain. Methylation of Lysine 79 in Histone 3 acts as a marker of inactive chromatin regions. Methylation by Dot1 methylase on lysine-79 (Lys79) of Histone H3 is criticial for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen monomethyl Histone H3 (Lys79)
Applications Western Blot
Classification Monoclonal
Clone RM147
Formulation Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.
Gene Accession No. P84243
Gene Symbols H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B
Host Species Rabbit
Immunogen A linear peptide corresponding to human Histone H3 monomethylated at Lys79.
Purification Method Protein A Purfied
Quantity 100 μg
Regulatory Status RUO
Research Discipline Epigenetics and Nuclear Function
Primary or Secondary Primary
Target Species Human
Content And Storage Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Form Purified
Isotype IgG
Show More Show Less

For Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.