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MSR1 Rabbit anti-Bovine, Dog, Horse, Human, Mouse, Primates, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89115756 Shop All Abnova Corporation Products
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89-115-756 100 μL
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Catalog No. 89-115-756 Supplier Abnova Corporation Supplier No. PAB12380
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Description

Rabbit polyclonal antibody raised against synthetic peptide of MSR1.

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq]

Specifications

Antigen MSR1
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of MSR1.
Dilution Immunocytochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (30% glycerol, 0.09% sodium azide)
Gene MSR1
Gene Alias CD204/SCARA1/SR-A/phSR1/phSR2
Gene Symbols MSR1
Host Species Rabbit
Immunogen A synthetic peptide (cyclic form) corresponding to amino acids 300-400 of human MSR1.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4481
Target Species Bovine, Canine, Equine, Human, Mouse, Primate, Rat
Content And Storage Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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