MSR1 Rabbit anti-Bovine, Dog, Horse, Human, Mouse, Primates, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MSR1.

Supplier:  Abnova Corporation PAB12379

Catalog No. 89-115-754

Description

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq]

Specifications

• Antigen: MSR1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of MSR1.
• Formulation: In PBS (30% glycerol, 0.09% sodium azide)
• Gene Alias: CD204/SCARA1/SR-A/phSR1/phSR2
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Canine, Equine, Human, Mouse, Primate, Rat
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Dilution: Immunocytochemistry (1:50-1:200) Immunofluorescence (1:50-1:200) Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: MSR1
• Gene Symbols: MSR1
• Immunogen: A synthetic peptide (linear form) corresponding to amino acids 300-400 of human MSR1.
• Regulatory Status: RUO
• Gene ID (Entrez): 4481
• Content And Storage: Store at 4°C for short term. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only